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date: 01 October 2022

Down Syndrome From a Neurodevelopmental Perspectivelocked

Down Syndrome From a Neurodevelopmental Perspectivelocked

  • Eloisa Tudella, Eloisa TudellaUniversidade Federal de São Carlos
  • Meyene Duque Weber, Meyene Duque WeberUniversidade Federal de São Carlos
  • Carolina Fioroni Ribeiro da SilvaCarolina Fioroni Ribeiro da SilvaUniversidade Federal de São Carlos
  •  and Cristina Hamamura MoriyamaCristina Hamamura MoriyamaUniversity of São Paulo


Down syndrome (DS) is the most common chromosomal condition associated with intellectual disability. Individuals with DS have restrictions on social participation. In addition, affected body structures and functions and activity limitations may lead to incapacity and impact individuals, families, health systems, and society. Evidence suggests using a window of therapeutic opportunity in early childhood when neuroplasticity is intense and that it is essential to plan treatment strategies for different phases of life. Pharmacological interventions have also been studied to improve cognitive performance, but effectiveness has not been proven. Nevertheless, early clinical interventions (e.g., physical therapy, occupational therapy, and speech therapy) are recommended to help children with DS acquire developmental milestones. The literature presents strong biopsychosocial and economic arguments for early intervention, starting with protection, support, and promotion of development of individuals with DS from conception to aging.


  • Developmental Psychology

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