One of the most complex words in the English language, “nature” (sometimes personified as “Nature” or “Mother Nature”) has been central to developments in American religions. Despite their different origins, the three cosmologies present on the North American continent during the early modern “age of contact”—Native American, African American, and Euro-American—shared a number of similarities, including the belief in an enchanted or animate cosmos, the ambivalence of sacred presences manifested in nature, and the use of myth and ritual to manage these ambivalent presences in ways that secured material and spiritual benefits for individuals or communities. Through encounters on colonial borderlands and through developments in society and culture (in science, economics, politics, etc.), these cosmologies have been adapted, developed, and combined in creative ways to produce new forms of religious life. These developments have been characterized by a series of recurrent tensions, including the notion of divine or spiritual realities as being transcendent or immanent, organicism or mechanism, and of the natural world as including or excluding human beings. Organicist and animist cosmologies, severely challenged by the early modern scientific revolution, were resurgent in the antebellum period, fueling a series of new religious developments, from Transcendentalism and revivalism to Mormonism and the early environmentalist movement. These generative tensions continue to reverberate into the modern day, in part as an outworking of the environmental crisis of the 1960s, which saw a purported “greening” of established religions as well as the rise of new forms of nature spirituality.