In its broadest sense, interracialism in American Christianity refers to constructive social interactions and collaboration across racial and ethnic boundaries—existential engagement inspired by religious ideals and religious teachings—in the interest of undercutting sanctioned divisions. Terms such as “racial interchange,” “desegregation,” “integration,” and “cross-racial” also refer to the broader ideas contained in the term “interracial.” To single out Christianity as a subject of interracial dynamics in American religious history does not deny the existence of cross-racial experiences in other religious traditions such as Buddhism, or even in the various groups within new religious movements. Rather, it reflects the largest range of documented experiences on this subject and synthesizes the major scholarship on this topic. The existence of interracialism in American religion also assumes the entanglement of race and religion. As social constructs, religious ideas and teachings contributed to conceptions of race and its lived realities, while notions of race shaped the development of religious practices, religious institutions, and scriptural interpretations. Interracialism in American religion is a concept that portends the possibility of political, social, or intellectual unity; in practice it wrestles with power dynamics where factors such as class or gender, as much as race, shapes social relations. In other words, interracialism in American religion has been a transgressive, disruptive presence that defies structures of power; at the very same time, it has exhibited social and expressive habits that reinforce existing arrangements of exploitation and division. Interracialism in American religion has existed in the course of everyday, ordinary human interaction through the spoken and written word, friendship, or sexual relations, for example. Simultaneously, interracialism in American religion has been the programmatic focus of institutional programs or initiatives, carried out by religious leaders and organizations, or supported through denominational efforts. The history of interracialism in American Christianity registers potential for unity or collaboration, while it is always subject to the pitfalls of power relations that subvert the vitality and beauty that are possible through shared experience. Protestant and Catholic Christianity have manifested the most extensive expressions of interracialism in American religion. Interracialism in American religion is in one sense as old as American religious history itself; however, given the racial discrimination written into the nation’s legal code, political system, and economic practice, interracial engagement most especially dawned at the beginning of the 20th century followed by century-long developments that continued into the first decade of the 2000s. Interracialism in American religion is a subject with longitudinal dimensions and contemporary resonance. Enduring and timely, its scholarly provenance spans across many disciplines including the fields of history, theology, literature, and social science. As the scholarship on the subject demonstrates, interracialism and racial interchange rarely produced racial harmony and did not necessarily lead to integration or desegregation; however, these impulses created specific moments of humane recognition that collectively contributed to substantive changes in the direction of racial and social justice.