The concept of White supremacy is introduced and its impact on society and the social work profession is examined. The ideological and historical foundations of Whiteness in the United States are summarized, and an overview is provided of the legal supports that codified White supremacist ideas into structural racism. White supremacy’s influence on social work is discussed, with an emphasis on language and concepts, history, pedagogy, and organizations. Critical theory and practice frameworks are explored as responses to White supremacy. The limitations of social work’s responses and specific implications for macro social work are discussed.