This article presents an integrated perspective and framework for global practice toward achieving the Global Agenda developed by international social work organizations. First, it presents “global practice” as a progressive, comprehensive, and future-oriented term that encompasses social work and social, economic, and sustainable development at multiple levels: local, national, regional, international, multinational, and global. Second, it discusses the origin and 21st-century understanding of the Global Agenda for social work. Third, it deliberates on ways of moving forward on the Global Agenda at multiple levels through an integrated perspectives framework consisting of global, ecological, human rights, and social development perspectives to guide practice. Finally, it concludes that global practice and the Global Agenda need to be translated into local-level social work and development practice and local-level agendas, making a case for social work and sustainable social development leadership and practice at grassroots and national levels.