During the 21st century, professional organizations such as the National Association of Social Workers have sanctioned standards for religious competence in social work practice and education. Social work practitioners and students are expected to receive training and education in spirituality. While content on Islam and Muslims is emerging in the professional literature, this is the first article in the Encyclopedia to explore the relatedness between the teachings of the Islamic faith and the social work profession. The Muslim population in the world, and in the United States specifically, is described briefly, along with an overview of intra-faith diversity. Social work practice with Muslims can be enhanced substantially when practitioners are aware of the worldview of Muslims and core Islamic values. In addition, practitioners should be familiar with Islamic teachings within a historical and professional context. Micro and macro level practice strategies and approaches are presented with a special emphasis on social work values and ethics. Lastly, practice principles for religion-sensitive practice with clients who self-identify as Muslims are delineated.