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Cross-cultural measurement is an important topic in social work research and evaluation. Measuring health related concepts accurately is necessary for researchers and practitioners who work with culturally diverse populations. Social workers use measurements or instruments to assess health-related outcomes in order to identify risk and protective factors for vulnerable, disadvantaged populations. Culturally validated instruments are necessary, first, to identify the evidence of health disparities for vulnerable populations. Second, measurements are required to accurately capture health outcomes in order to evaluate the effectiveness of interventions for cross-cultural populations. Meaningful, appropriate, and practical research instruments, however, are not always readily available. They may have bias when used for populations from different racial and ethnic groups, tribal groups, immigration and refugee status, gender identities, religious affiliations, social class, and mental or physical abilities. Social work researchers must have culturally reliable and valid research instruments to accurately measure social constructs and ensure the validity of outcomes with cultural populations of interest. . In addition, culturally reliable and valid instruments are necessary for research which involves comparisons with different cultural groups. Instruments must capture the same conceptual understanding in outcomes across different cultural groups to create a basis for comparison. Cross-cultural instruments must also detect and ascertain the same magnitude in the changes in health outcomes, in order to accurately determine the impact of factors in the social environment as well as the influence of micro, mezzo, and macro-level interventions. This reference provides an overview of issues and techniques of cross-cultural measurement in social work research and evaluation. Applying systematic, methodological approaches to develop, collect, and assess cross-cultural measurements will lead to more reliable and valid data for cross-cultural groups.