The compounding and escalating effects of environmental degradation, which include climate change, threaten the human-earth system with severe implications for the future of macro social work. Systems of power and oppression, including racial, economic, and gendered inequities, are exacerbated by environmental changes with significant impacts on human rights, public health, and various measures of well-being. While climate change is often not the root cause of inequality, it compounds existing inequities, making it substantially more difficult for marginalized populations to rebound from escalations of the myriad acute and chronic consequences due to climate change and environmental collapse. Experiences of environmental change consistently highlight the expanding resource and resiliency gaps among vulnerable populations, leading to disproportionate repercussions felt initially and, to an arduous degree, by marginalized groups. Simultaneously, these circumstances create opportunities for social workers to intervene and advance the causes of social justice. Macro-level interventions and climate solutions can emerge from social work development and support of policies and interventions that overcome short-term thinking to produce beneficial outcomes for populations and the environment by building capacity in the human-earth system and economic policy systems. Social work is ideally situated to confront climate change by balancing immediate needs with long-term ecological sustainability and relying on its historical understanding of systems to improve policy development and practical climate change mitigation approaches.