Charter schools were founded as a new kind of public school that valued integration, autonomy, and innovation. However, the overall performance of charter schools has been mixed. While positive findings related to the performance of charter schools have been reported, a number of controversial issues and practices involving charter schools have also been identified in the literature. As the number of charter schools continues to grow, the demand for school social work practice in charter schools will also increase. Since a major focus of school social work practice is serving and advocating for at-risk students and their families, this article highlights several issues that have particular relevance for school social work practice serving at-risk students and their families in charter schools and proposes interventions designed to assist at-risk students and their families. These issues are: assisting parents of at-risk students with the application process, advocating for practices to enhance the long-term academic achievement of at-risk students, and equipping at-risk students with skills to meet the behavioral demands of “no excuses” charter schools.