The paper presents a global scenario of child labor by placing the issue in a historical context as well as comparing current work in the field. It specifically explains the psychosocial, political, and economic determinants of child labor and the prevalence of different forms as well as its magnitude in the different regions of the world. It features innovative programs and actions taken against child labor by local governments, civil societies, and United Nations bodies—mainly the International Labor Organization and the United Nations Children’s Fund. The paper also highlights multilateral collaborations among the UN and other international agencies that stand against child labor in general and the employment of children in hazardous conditions. It illustrates the cooperation among local governments, civic organizations, and child-rights movements that have brought gradual changes over the decades toward ending child labor. Further, it suggests that social work, relevant professional schools, and associations working in various disciplines should be engaged in research-based advocacy and find innovative solutions to control child labor.