This article offers an introduction to macro social work practice interventions. Specifically, it seeks to: (a) identify the difference between direct service (micro) and macro practice; (b) describe historical and contemporary foundations for macro practice; (c) establish a connection between macro practice and core social work values; (d) describe specific examples of macro social work practice using 21st-century social justice issues as exemplars; and (e) identify roles needed for macro social work practice. This article emphasizes the need for macro social work practice to create much needed change in the areas of social, environmental, and economic justice. It will examine the trend in social work that has increasingly placed emphasis and value on micro practice, which has marginalized macro-level social work as a result. Society continues to confront seemingly intractable social justice issues and is, in the early 21st century, experiencing a critical reckoning of how systems of oppression continue to exact violence against vulnerable populations. This article uses examples of social, environmental, and economic justice issues with specific recommendations on how to adopt an anti-oppressive macro practice framework.