This article describes issues related to culturally competent social work practice with religiously fundamentalist families in public school settings. It addresses the history of religious fundamentalist identities, the complexity inherent in such identities, and the nature of fundamentalism. A review of issues related to culturally competent practice in educational settings is offered. Recommendations informed by spiritually sensitive and strength-based approaches are discussed. Challenges to working effectively with religiously conservative and fundamentalist families in educational settings are also explored. Emphasis is placed upon the practitioner’s role in developing spirituality-sensitive therapeutic relationships by improving religious literacy, developing enhanced self-awareness, and approaching clients from a perspective of cultural humility and a lens of intersectionality.