Although the year 2000 marked the first time U.S. citizens were allowed to report more than one race in the Census, multiraciality and multiethnicity are certainly not new in the United States or globally. The history of multiracial America is inextricably linked to its history of immigration, slavery, racism, and the very construction of single-race identities as master statuses during colonialism. Who is multiracial, as well as the idea that such an identity or population can or should exist, is highly complex and has shifted along with societal attitudes and laws governing race identity options and the sanctioning of multiracial families through marriage and adoption. The understanding in the early 21st century of this growing multiracial population is mired in this history, but also idealized as proof of a new and possibly “postrace” America. To examine multiraciality, this entry begins by defining root concepts including race, ethnicity, nationality, and culture to then examine and define multiraciality. This entry will include a brief historical discussion of multiraciality in the United States and will also explore demographic and health trends using such statistics as are available and examine identified risks, disparities, strengths, and resiliencies among this diverse population. Effective and ethical social-work practices with multiracial persons require expansion beyond the black–white dichotomy and monocentric paradigm of race to consider both strengths and vulnerabilities navigated by the increasing number of persons and families who identify as multiracial and multiethnic. Approaches to social work that promote multiracially attuned practices and engagement of the diverse resources for various communities of multiracial persons and families conclude this entry.